1290 Infinity II Autoscale Preparative LC/MSD System

The 1290 Infinity II Autoscale Preparative LC/MSD System is the ultimate workflow solution for direct scale-up from analytical scouting to gram-level purification of target compounds.

Agilent automated purification software enables automated method transfer from analytical to preparative-scale purification. Mass-selective fraction triggering streamlines your purification processes and helps boost laboratory efficiency.



  • Preparative LC/MSD System with automated combined sample injection and fraction collection enables scale-up from analytical to preparative chromatography on one single system to maximize your capacity and increase your daily throughput
  • Support of automated workflows through import and export of sample sequences while focusing solely on your target compounds to minimize re-analysis time and reformulation of collected fractions
  • Highly reliable and robust LC system improves your ability to manage ever-increasing workload demand
  • Easy-to-change pump heads provide dynamic flow range up to 200 mL/min at maximum 600 bar for versatile application within a wide range of preparative workflows
  • Control and organization of valves: Five multipurpose slots provide enhanced organization of valves, fraction delay coils, and Agilent 1290 Infinity II MS Flow Modulator for a significant increase in productivity
  • Integration of all standard collection modes and compatibility with multiple trigger sources provides compatibility to existing purification methods
  • Lowest delay volume to minimize peak dispersion and carry-over for the highest sample recovery and purity
  • Clean software infrastructure through Agilent OpenLab CDS ChemStation for familiar and reliable operation
  • Automated purification software opens the door to workflow automation to scale-up from analytical to preparative conditions based on scientific algorithms – eliminates the need for time-consuming method development to improve daily purification cycles
  • Integrated leak sensor in each module shuts down the whole system; providing additional safety when detecting a leak

How it works



Biocompatible No
Bioinert No
Column Capacity 10
Column ID Reader Option No
Depth 622 mm
Flow Range 1-200 mL/min
Injection Range 5-15700 µL
Intelligent System Emulation Technology No
Line Voltage 100-240 VAC
Maximum Number of Fractions 432
Maximum Number of Solvents 4
Pump Type Binary
Special Features Delay Sensor

Automated Delay Volume Calibration

Analytical-to-preparative work

System Pressure Operating Range 20-600 bar
Width 2181 mm