1260 Infinity II Bio-SEC Multi-Detector System

The 1260 Infinity Multi-Detector Bio-SEC System is completely metal-free and comprises light scattering and dynamic light scattering to allow determination of protein shape and size without the need for SEC column calibration. Size exclusion chromatography (SEC) is the standard method to determine and quantitate monomers, dimers, aggregates, and potential degradants and is a common requirement for regulatory approval. The detector has a simple low dead volume interface to the 1260 Infinity II Bio-inert LC


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  • Light scattering detection provides reproducible and accurate molecular weight information independent of a column calibration created using narrow distribution polymer standards
  • Possible to identify and characterize oligomers, and at the same time view information regarding aggregation and folding effects
  • Market-leading, low-dead-volume, light scattering detection minimizes any peak band broadening to ensure absolute molecular weights
  • Same flow cell used to also perform dynamic light scattering measurements (e.g., details regarding size in solution, known as hydrodynamic radius (or Rh))
  • Precise detail possible because globular proteins are assymetric scatterers




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