1290 Infinity II Preparative LC/MSD System

The 1290 Infinity II Preparative LC/MSD System enables high-throughput purification, delivering high-quality compounds, for example, for biological screening, an important part of drug discovery.

This system features the Agilent 1290 Infinity II Preparative Open-Bed Sampler/Collector and offers outstanding flexibility in terms of application area and bench space. Mass-selective fraction triggering streamlines your purification processes and helps boost laboratory efficiency by reducing your reanalysis time.


  • Preparative LC/MSD System with fully automated combined sample injection fraction collection to maximize your capacity to increase your daily throughput, maximize purity, and minimize reanalysis time by mass-based purifcation
  • Focusing solely on your target compounds to minimize reanalysis time and reformulation of collected fractions
  • Highly reliable and robust LC system improves your ability to manage ever-increasing workload demand
  • Easy-to-change pump heads provide dynamic flow range up to 200 mL/min at maximum 600 bar for versatile application within a wide range of preparative workflows
  • Control and organization of valves: five multipurpose slots provide enhanced organization of valves, fraction delay coils, and Agilent 1290 Infinity II MS Flow Modulator for a significant increase in productivity
  • Integration of all standard collection modes and compatibility with multiple trigger sources provides compatibility to existing purification methods
  • Lowest delay volume to minimize peak dispersion and carry-over for the highest sample recovery and purity
  • Clean software infrastructure through Agilent OpenLab CDS ChemStation for familiar and reliable operation

How it works



Biocompatible No
Bioinert No
Column Capacity 10
Column ID Reader Option No
Depth 622 mm
Flow Range 1-200 mL/min
Injection Range 5-15700 µL
Intelligent System Emulation Technology No
Line Voltage 100-240 VAC
Maximum Number of Fractions 432
Maximum Number of Solvents 4
Pump Type Binary
Special Features Delay Sensor

Automated Delay Volume Calibration

System Pressure Operating Range 20-600 bar
Width 1585 mm