400-DS Apparatus 7

The Agilent 400-DS Apparatus 7 is an instrument that enables simultaneous, small volume dissolution testing of up to 13 samples. The 400-DS is designed for testing novel dosage forms, allowing users to carry out combination products dissolution testing and evaluations. The innovative design incorporates both the dissolution apparatus and the autosampler.

Operated by software designed to comply with 21 CFR Part 11 guidelines, the 400-DS Apparatus 7 offers convenience, increased throughput, and efficiency to your QC and R&D operations. The system can be customized to your needs to hold drug-eluting stents, pacemaker leads, medicated contact lenses, catheters, and more.

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  • Performs automated small-volume dissolution testing using as little as 3 mL media volume in either 5 or 10 mL sample cells
  • Saves time by simultaneously testing up to 13 samples, or 12 samples and a control or standard, while providing users direct visibility of each dissolution cell
  • Maintains temperature control through internal temperature probes and external heating jackets—no water bath is required
  • Minimizes evaporation through the fully closed system
  • Integrated syringe pump and autosampler save valuable bench space
  • Offers automated media addition/removal of up to five different types of media through a port on the bottom of the cell
  • Enables sample holder reciprocation through an externally controlled magnetic plate and supports between 1 and 35 dips per minute (DPM) to best match your requirements
  • Accommodates 12 individual sample rows with either 2 or 4 mL HPLC vials for unattended sample collection
  • Allows you to program up to 36 timepoints and five different media types into a method, with software prompts for the removal and replacement of the racks during the run
  • Automates full or partial media replacement at each timepoint via a built-in fluidics module for each sample cell
  • 21 CFR Part 11 compliant software and a single PC can independently control up to four 400-DS systems




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