Glycopeptide Characterization for Various Monoclonal Antibodies Using the Agilent 6545XT AdvanceBio LC/Q-TOF

Monoclonal antibodies (mAbs) and their derivatives represent a very complex but important class of biopharmaceutical molecules with a wide range of applications. As mAbs are heterogeneous molecules by nature, comprehensive analytical characterization is required. The full range of biotherapeutics characterization usually includes confirmation of the protein sequences, protein post-translational modification (PTM) locations, and their relative quantitative information. Protein glycosylation is one of the major PTMs of an mAb, and is involved in many biological regulatory processes as well as therapeutic efficacy and immunogenicity1 . Therefore, it is important to understand the various glycans’ distribution and composition for pharmaceutical bioprocessing

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