There are >1,000 pesticides used globally, and food safety laboratories are under pressure to widen the scope of their analytical methods for routine pesticide monitoring. As a result, method development and data analysis have become a time-consuming and labor‑intensive task for analytical laboratories. To address this growing issue, Agilent has developed the MassHunter Productivity App, which streamlines routine, high-throughput quantitation workflows in food testing laboratories. This Application Note demonstrates the capabilities of the software for multiresidue screening of 254 pesticides in two matrices, using the Agilent Ultivo triple quadrupole LC/MS.